Buy VP10 Peptide (VIP 10-28 Fragment) — 10mg Lyophilized Powder Vials
Research Notice: All products listed on this e-commerce storefront are available exclusively for in vitro laboratory experimentation, chemical analysis, and scientific research usage. These compounds are not approved for human consumption, therapeutic use, or medical administration.
Technical Specifications
| Technical Specification | Value / Detail |
|---|---|
| Product Name | VP10 Peptide |
| Alternative Name | Vasoactive Intestinal Peptide (10-28) Fragment |
| CAS Registry Number | 69856-17-3 |
| Amino Acid Sequence | Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 |
| Molecular Formula | C105H180N32O26S |
| Molecular Weight | 2338.87 g/mol |
| Purity Level | Greater than or equal to 99% (HPLC/MS Lab Verified) |
| Physical Format | Sterile, white freeze-dried powder vial |
Purchasing Options
Our laboratory store offers premium, synthetic VP10 peptide 10mg vials engineered for high-purity chemical testing. As an established research chemical vendor, we ensure reliable stock availability, fast logistical transit, and strict quality controls. If you are looking to purchase bulk peptide supplies for multi-stage experimental trials, custom wholesale tier pricing options are accessible via our support office.
Consequently, buying your materials from an unverified supplier can ruin your study datasets. Therefore, we preserve every batch in climate-controlled environments before dispatch. This attention to detail guarantees that your experimental environment receives completely uncompromised chemicals.
Bulk Pricing Breakdown
Bulk Pricing Breakdown
Order Quantity | Price Per 10mg Vial | Expected Delivery Timeline
- 1 – 4 Vials: $79.00 USD | 2 to 3 Business Days
- 5 – 9 Vials: $71.00 USD | 2 to 3 Business Days
- 10 – 24 Vials: $63.00 USD | Free Express Shipping (1-2 Days)
- 25+ Vials (Wholesale Bulk): Contact Account Representative | Tailored Freight Manifest
Quality Assurance
Every batch of our 10mg research vials undergoes high-performance liquid chromatography (HPLC) and mass spectrometry (MS) evaluation. A physical Certificate of Analysis (CoA) accompanies your order to verify that your batch meets or exceeds the mandatory 99% purity standard. This verification ensures reproducible data across your laboratory assays.
Furthermore, we use vacuum-sealed amber glass vials to package our compounds. Because light exposure and moisture cause immediate degradation, this packaging protocol offers critical protection. Thus, our meticulous containment allows the compound to maintain uniform structural integrity during long-range transport.
Research Mechanisms
In vitro models demonstrate that the VIP (10-28) fragment acts as a highly effective competitive antagonist at VIP receptor sites. In laboratory tests using HT29 colonic adenocarcinoma cultures, the VP10 fragment binds to target receptors securely without activating downstream cyclic AMP (cAMP) synthesis. This specific binding profile makes it a crucial control compound for isolating VPAC1 and VPAC2 receptor responses.
In addition, researchers frequently utilize this 19-amino acid carboxyl-terminus truncated sequence to map the exact binding domains of native Vasoactive Intestinal Peptide. Because the fragment lacks the internal activation sequence, it effectively blocks endogenous VIP from triggering cellular cascades. Consequently, this blockade provides clear data regarding G-protein coupled receptor regulation pathways.
Key Cellular Interaction Triggers
Receptor Target | Mechanism Type | Direct Experimental Outcome
- VPAC1 Receptor: Competitive Antagonist | Blocks cyclic AMP (cAMP) synthesis activation
- VPAC2 Receptor: High Affinity Antagonist | Inhibits downstream intracellular signaling cascades
- Macrophage Profiles: Neuroimmune Modulator | Triggers measurable upregulation of biological markers
Vasodilation Studies
Physiological data shows that the VIP 10-28 sequence serves a significant role in tracking skin blood flow changes under hyperthermic stress. Microdialysis experiments indicate that administering this specific peptide fragment attenuates the typical elevation of localized blood flow during heat exposure. Investigators purchase this compound to analyze chemical pathways linking nitric oxide synthase and histamine reactions.
Meanwhile, multiple comparative laboratory studies highlight how the compound alters systemic heat dispersal models. Because local blood vessels exhibit a diminished dilation response when researchers apply the antagonist, the experiment confirms the primary vasodilatory role of native VIP. Therefore, this unique interaction establishes the VP10 fragment as an essential tool in cardiovascular and thermal regulation research.
Neuroimmune Signaling
Native VIP naturally modulates the immune system by downregulating specific pro-inflammatory cytokines such as TNF-alpha and IL-6. By implementing the VP10 fragment in active research models, scientists can selectively block these pathways. This isolation assists in mapping how neuroendocrine systems interact with automated inflammatory responses.
As a result, laboratories globally acquire this compound to examine the delicate line between neurogenic inflammation and autoimmune homeostasis. For example, if you introduce the antagonist into a macrophage cellular environment, you can easily monitor the accelerated upregulation of inflammatory biological markers. This specific experiment clarifies the vital protective mechanisms that endogenous neuropeptides naturally provide.
Chemical Architecture
To achieve accurate results during your automated assay procedures, your team must understand the deep structural layout of the VIP (10-28) fragment. Our product features a strictly synthesized sequence containing nineteen specific amino acid chains. Because this exact structure mimics the exact binding affinity of native human, porcine, and rat VIP, it ensures translatable across multi-species comparative academic research.
Furthermore, the molecular weight sits precisely at 2338.87 g/mol. Our engineers perform structural optimization during the synthesis phase to minimize common peptide fragmentation anomalies. Because we enforce these rigorous internal benchmarks, our inventory stands out as the premier marketplace option for demanding biochemical testing workflows.
FAQ
Shipping Logistics
How is shipping managed for 10mg peptide vials?
Our 10mg vials are shipped as highly stable, lyophilized (freeze-dried) powder. This format allows the peptide to endure standard ambient temperatures during transit without losing biological activity or experiencing structural breakdown. For this reason, domestic and international shipments do not strictly require ice packs during standard shipping windows.
Billing Protocols
What payment methods are accepted at checkout?
Our secure checkout platform accommodates major credit cards, bank wire transfers, and verified corporate purchase orders. All purchase data is fully encrypted to protect your billing and institutional privacy. If you encounter any technical checkout issues, our customer care staff can process your laboratory invoice manually.
Laboratory Handling
How should the product be handled upon delivery?
For long-term storage, keep the unopened lyophilized vials frozen at -20°C. Once reconstituted for active laboratory testing, keep the liquid solution refrigerated at 4°C and use it within 14 days to prevent compound degradation. Therefore, we highly suggest calculating your exact fluid volumes before beginning the reconstitution phase.
Bulk Orders
Can I obtain bulk wholesale discounts for large-scale clinical screens?
Yes, we offer deep tiered discounts for universities, private biotech operations, and contract research organizations (CROs). Please reach out via our official wholesale portal with your estimated monthly vial requirements. Afterwards, a commercial account specialist will compile a tailored quote containing customized shipping manifests.
Academic Citations
- VIP Receptor Modulation: A fragment of vasoactive intestinal peptide, VIP(10-28), is an antagonist of VIP in the colon carcinoma cell line. PubMed Study ID: 3025826.
- Vasodilation & Thermoregulation: Vasoactive intestinal peptide fragment VIP 10–28 and active vasodilation in human skin. Journal of Applied Physiology.
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